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Importantly, the inhibitory effect of HS decoction on viral replication was abolished by an anti MIR2911 antagomir, indicating that the physiological power of MIR2911 in HS decoction could directly and sufficiently suppress H1N1 viral replication. MIR2911 also inhibited H5N1 and H7N9 viral replication in vitro as well as in vivo. Strikingly, administration of MIR2911 or HS decoction dramatically reduced mouse mortality attributable to H5N1 infection..
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